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Islet cell transplantation print that page


Islets are usually infused into the patient's liver ,. [ 1 ] The patient's body, however, will treat the infused islets just as it would any other introduction of foreign tissue: the immune system will attack the islets as it would a viral infection, leading to the risk of transplant rejection

Insulin print that page


status is also used as a control signal to other body systems (such as amino acid uptake by body cells ). In addition, it has several other anabolic effects throughout the body. When control of insulin levels fails, diabetes mellitus will result. As a consequence, insulin is used medically

Islets of Langerhans print that page


The islets of Langerhans are the regions of the pancreas that contain its endocrine (i.e., hormone-producing) cells . Discovered in 1869 by German pathological anatomist Paul Langerhans at the age of 22, [ 1 ] the islets of Langerhans constitute approximately 1 to 2% of the mass of

Langerhans cell print that page


The Langerhans cell is named after Paul Langerhans , a German physician and anatomist , who discovered the cells at the age of 21 while he was a medical student . [ 4 ] Because of their dendritic nature, he mistakenly identified the cells as part of the nervous system . [ 5 ] [ edit

Paul Langerhans print that pageTimeline of Paul Langerhans


Contributions to the microscopic anatomy of the pancreas ”, in which he refers to islands of clear cells throughout the gland, staining differently than the surrounding tissue. He noticed that these areas were more richly innervated, but he could not suggest a function, except for the

Beta cell print that page


Beta cells make and release insulin , a hormone that controls the level of glucose in the blood. There is a baseline level of glucose maintained by the liver, but the beta cells can respond quickly to spikes in blood glucose by releasing stored insulin while simultaneously producing more

Diabetes mellitus print that page


juvenile diabetes.) Type 2 diabetes : results from insulin resistance , a condition in which cells fail to use insulin properly, sometimes combined with an absolute insulin deficiency. (Formerly referred to as non-insulin-dependent diabetes mellitus, NIDDM for short, and adult-onset

Glucagon print that page


The hormone is synthesized and secreted from alpha cellscells ) of the islets of Langerhans , which are located in the endocrine portion of the pancreas. In rodents, the alpha cells are located in the outer rim of the islet. Human islet structure is much less segregated, and alpha

Diabetes management print that page


requiring management is the glucose cycle, whereby glucose in the bloodstream is made available to cells in the body, a process dependent upon the twin cycles of glucose entering the bloodstream, and insulin allowing appropriate uptake into the cells of the body. Both aspects can require

Frederick Banting print that pageTimeline of Frederick Banting


had indicated that diabetes was caused by lack of a protein hormone secreted by the Islets of Langerhans in the pancreas. To this hormone Schafer had given the name insulin. It was supposed that insulin controls the metabolism of sugar, so that lack of it results in the accumulation of sugar