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HLA-DR print that page


presented to a few of a great many T-cell receptors found on T-helper cells. These cells then bind to antigens on the surface of B-cells stimulating B-cell proliferation. Contents 1 Function 2 Structure 3 Genetics 3.1 Evolution and Allele Frequencies 4 Serogroups 5 Interlocus

History and naming of human leukocyte antigens print that page

A person can have 2 antigen proteins per genetic-locus (one gene from each parent). During development the immune system determines these two antigens are 'self' antigens or ( autoantigens ) and turns off the destructive response. However when tissues are transferred to another person they

wikipedia.org | 2010/9/26 21:18:56

CD19 print that page

CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells . It primarily acts as a B cell co-receptor in conjunction with CD21 and

wikipedia.org | 2011/5/25 0:53:00

HuD (protein) print that page


The HuD/ELAVL4 protein is an RNA-binding protein . [ 3 ] HuD is expressed only in neurons and it binds to AU-rich element -containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity. [

Superantigen print that page

one of the fundamental strengths of the adaptive immune system , that is, its ability to target antigens with high specificity. More importantly, the large number of activated T-cells secrete large amounts of cytokines (the most important of which is TNF-alpha ). TNF-alpha is particularly

wikipedia.org | 2011/2/22 10:41:57

Polyomavirus print that page

The genus Polyomavirus used to be one of two genera within the now obsolete family Papovaviridae (the other genus being Papillomavirus which is now assigned to its own family Papillomaviridae ). The name Papovaviridae derived from three abbreviations: Pa for Papillomavirus , Po for Polyomavirus

wikipedia.org | 2010/9/25 0:45:06

Humoral immunity print that page

process is aided by CD4+ T-helper 2 cells, which provide co-stimulation. Secreted antibodies bind to antigens on the surfaces of invading microbes (such as viruses or bacteria), which flags them for destruction. [ 1 ] Humoral immunity is so named because it involves substances found in the

wikipedia.org | 2011/5/11 7:35:58

MHC class I print that page

Class I MHC molecules bind peptides generated mainly from degradation of cytosolic proteins by the proteasome. The MHC I:peptide complex is then inserted into the plasma membrane of the cell. The peptide is bound to the extracellular part of the class I MHC molecule. Thus, the function of the

wikipedia.org | 2011/5/22 4:39:03

CD1 print that page

In humans [ edit ] Group 1 Group 1 CD1 molecules have been shown to present foreign lipid antigens , and specifically a number of mycobacterial cell wall components, to CD1-specific T cells. [ edit ] Group 2 The natural antigens of group 2 CD1 are not well-characterized, but a synthetic

wikipedia.org | 2011/4/21 0:54:29

MHC class II print that page

open at both ends while the corresponding groove on class I molecules is closed at each end, the antigens presented by MHC class II molecules are longer, generally between 15 and 24 amino acid residues long. [ edit ] Reaction to bacteria Because class II MHC is loaded with extracellular

wikipedia.org | 2011/5/11 13:12:10